Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Machine Learning Engineer, AI Studio What You Will Do Lets do this. Lets change the world. In this vital role you will bepart of AI Studio anddefine and own AI assetsor substantial technical workstream from problem framing through architecture, model and system development, evaluation, launch, stabilization, support transition,adoptionand measurable outcome. You will remain hands-on while leading decisions across software, statistics, classical ML, deep learning, NLP, GenAI, RAG, bounded agents, data and knowledge pipelines, APIs,MLOps/LLMOps, security,governanceand operations. Within Applied AI-AI Studio turn prioritized business demand into governed, reusable AI assets with accountable ownership and measurable value across software, data, automation, machine learning, Generative AI, RAG, bounded agents, evaluation,observabilityand lifecycle operations. Key Responsibilities • Define the user, workflow, decision, intended use, baseline, value hypothesis, acceptance criteria, adoption path, operatingownerand measurable technical and business outcomes. • Map rules, exceptions, datadependenciesand human decision points before selecting deterministic automation, classical ML, deep learning, GenAI, RAG,agentsor a manual approach. • Own production architecture across data, feature and knowledge pipelines, models, retrieval, agents, APIs, persistence, workflows, user experience, securityzonesand human review. • Lead hands-on development of production software, EDA, feature engineering, predictive models, deep-learning or NLP components, inference services, RAG, agenttoolsand workflow orchestration. • Establish baselines, experiment design, leakage controls, uncertainty, calibration, subgroup and robustness checks, gold sets, error taxonomies, expertadjudicationand release thresholds. • EstablishMLOps/LLMOpsfor lineage, reproducibility, versioning, CI/CD, canary or shadow release, observability, drift monitoring, SLOs, rollback, incidents, disaster recovery, capacity,costand runbooks. • Coordinate security, privacy, Responsible AI, Quality, legal, model-risk and GxP controls; create reusable capabilities, measure adoption and value, mentor engineers and improve delivery practices. What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The Senior Machine Learning Engineer we seek is a seasoned professional with these qualifications. Basic Qualifications Doctorate degree OR Masters degree and 2 years of experience in Computer Science,IT or related fields OR Bachelors degree and 4 years of experience in Computer Science,IT or related fields OR Associates degree and 8 years of experience in Computer Science,IT or related fields OR High school diploma / GED and 10 years of experience in Computer Science,IT or related fields Preferred Qualifications • Demonstrated end-to-end ownership of at least one production ML, GenAI, software, data or automation system that delivered a measurable outcome. • Strong hands-onproficiencyin Python and SQL, with experience designing production software,servicesand evaluation pipelines. • Advancecapability in at least one role-defining pillarApplied ML, GenAI/RAG/agentsor ML platform/MLOpsplus credible depth across the production lifecycle. • Advanced ML, causal and uncertainty methods: Experience with data-centric AI, weak supervision, active learning, conformal or Bayesian uncertainty, causal inference, time-series, survivalmethodsor drift-aware retraining. • Advanced deep learning and model efficiency: Experience with transformers, multimodal pipelines, CNNs, RNNs, GNNs, PEFT orLoRA, fine-tuning, distillation, quantization, routing,cascadesor inference optimization. • Cloud,platformand AI operations: Experience with AWS, Bedrock or SageMaker, Databricks, Spark, Kubernetes, serverless systems, infrastructure as code,MLflow, Airflow, Kubeflow, observability and FinOps. • Human-AI and regulated delivery: Experience with review, correction, approval, accessibility, uncertainty communication, workflow automation and GxP-relevant or validated systems. • Strong product thinking and ability to connect technical decisions to user, workflow, risk,costand business value. • Technical leadership, mentoring and constructive challenge whileremaininghands-on. • Excellent analytical judgment and clear communication of evidence, uncertainty,trade-offsand limitations. • Cross-functional leadership across business, product, architecture,engineeringand control functions. • Ownership, resilience and continuous improvement through incidents,feedbackand measured outcomes. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan • Stock-based long-term incentives • Award-winning time-off plans • Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.